Thibelo ea sethala sa ho ata ha thrombus

Ha ho pelaelo hore tsoelo-pele ea li-anticoagulants e khothalelitse ka ho toba phekolo ea DVT.Kalafo ea anticoagulant e ka thibela ho hlaha ha thrombus, ea thibela ho ata ha thrombus, ea thusa ho etsa autolysis ea thrombus le recanalization ea lumen, ea fokotsa matšoao, 'me ea fokotsa liketsahalo le lefu la pulmonary embolism.Hajoale, lithethefatsi tsa anticoagulant li kenyelletsa haholo heparin, heparin ea boima ba molek'hule e tlase, warfarin, rivaroxaban le dabigatran.E 'ngoe le e 'ngoe ea lithethefatsi tsena e na le melemo le melemo ea eona.Ha ho bapisoa le heparin e sa qhekelloang, heparin e boima ba molek'hule e tlase ka tlase kapa ka methapo e ka fokotsa lefu haholo.Har'a li-anticoagulants tsa molomo, warfarin e sebelisoa haholo ka lebaka la theko ea eona e tlaase, phello e nepahetseng ea anticoagulant ka har'a mefuta e sebetsang ea phekolo (e hlokang hore karolelano e tloaelehileng ea machaba e be pakeng tsa 2 le 3).Leha ho le joalo, hobane warfarin e angoa haholo ke lijo, ho bonolo ho ba le mathata a kang ho se lekane ha anticoagulation le ho tsoa mali, 'me hoa hlokahala ho shebella ts'ebetso ea coagulation kamehla.Lilemong tsa morao tjena, palo e kholo ea li-anticoagulants tse ncha li hlahile betheng, tse kang rivaroxaban, dabigatran, apixaban, joalo-joalo phello ea anticoagulant e nepahetse, mathata a ho tsoa mali a fokotsehile, 'me ha ho hlokahale ho hlahloba hape mosebetsi oa coagulation.

Hona joale, litsebi tse ling li fana ka maikutlo a hore phekolo ea lithethefatsi e ka aroloa ka mekhahlelo e 'meli ho ea ka karohano ea nako ea likhoeli tsa 3: mohato oa pele o bitsoa mohato oa pele oa phekolo o sebetsang.Haholo-holo e etsoa nakong ea likhoeli tse 3 ka mor'a ho qala ha dvt3, 'me mohato oa bobeli o bitsoa mohato oa ho thibela ho khutla hape, o etsoang likhoeli tse 3 ka mor'a mohato oa pele oa phekolo.Litaelo tsa Accp9 li khothalelitse li-anticoagulants tse ncha tsa molomo.Khatisong ea 10 ea tataiso ea American College of Chest Physicians (ACCP), phapang e kholo ka ho fetisisa ho tloha nakong e fetileng ke hore li-anticoagulants tse ncha tsa molomo (noac), tse kang factor Xa inhibitors (rivaroxaban, fondaparinux sodium, joalo-joalo) le factor IIA inhibitors ( dabigatran, joalo-joalo) li sebelisoa e le khetho ea pele bakeng sa phekolo ea VTE.Phekolo ea anticoagulant e na le phello e hlakileng, e fokotsa haholo mathata a ho tsoa mali, 'me ha e hloke tlhahlobo e ncha ea ts'ebetso ea coagulation.E ntse e khothaletsoa ho feta bakuli ba tloaelehileng.Li-anticoagulants tse ncha ka kakaretso li ka qoba ho hlaha hape ha DVT ka 80% ~ 92%.

Moeli oa phekolo ea anticoagulant feela ke hore le hoja phekolo ea anticoagulant e atisa ho sebelisoa ho fokotsa ho khutla ha thrombus le ho sireletsa mosebetsi oa li-valve tsa venous, e ke ke ea qhaqha thrombus kapele.Ho itšehla thajana ha thrombus ho bonoa ka seoelo ho bakuli ba nang le iliofemoral vein thrombosis, 'me thrombus e setseng e ka lebisa ho senyeha ha valve ea venous le tšitiso ea pampitšana ea ho tsoa, ​​e leng mabaka a bakang sekhahla se phahameng sa post thrombosis syndrome (PTS).Boithuto ba tlhokomeliso mabapi le ho hlaha ha PTS kamora kalafo ea anticoagulant ea DVT bo bonts'itse hore ketsahalo ea PTS e ne e le hoo e ka bang 20% ​​~ 50%, sekhahla sa seso sa venous sa maoto le matsoho a tlase e ne e le 5% ~ 10%, mme sekhahla sa venous claudication e ne e le 40% ka mor'a lilemo tse 5.Hoo e ka bang 15% ea bakuli ba ne ba e-na le mathata a ho sisinyeha, 'me boleng ba bophelo ba 100% ba bakuli bo fokotsehile ho ea ho tse fapaneng.